Starting HRT in early menopause can reduce women’s risk of Alzheimer’s

Beginning hormone replacement therapy (HRT) within five years of menopause of menopause appears to lower the risk of Alzheimer’s disease. Still, it seems to have the opposite effect to start it later in life, which suggests that the time of HRT affects how it affects the brain.

Women have an increased risk of developing Alzheimer’s disease compared to men, especially after reviewing menopause. This may be due to a decrease in the hormone estrogen that regulates energy production and inflammation of the brain. As such, HRT has emerged as a potential tool to mitigate Alzheimer’s risk after menopause. But studies of its effectiveness have shown mixed results.

Then FNU VAIBHAV at Pandit Bhagwat Dayal Sharma University of Health Sciences in India and his colleagues analysis of events of Alzheimer’s disease across 53 studies, a total of more than 8.4 million people. All the participants were postmenopausal.

They found in randomized-controlled trials, participants at HRT had an average of 38 per year. Like a greater risk of developing Alzheimer’s than those who were not. But that, if not the case with observation surveys, showering a 22 pr. A hundred lower risk of Alzheimer’s disease among those who take HRT.

Vaibhav, which presented these results on September 15 at a meeting of the American Neurological Association in Maryland, says the sharp contrast is likely to come to age. Most participants in the randomized controlled trials were 65 years or older, while in observation surveys they tended to be younger, he says. Further analysis showed an average of those who started HRT within five years of menopause, a 32 percent lower risk of Alzheimer’s disease during follow -up periods varied from five years in some studies to a person’s lifetime until death in others.

“This menopausal transition is recently a neurological transition,” says Roberta Brinton at the University of Arizona, who was involved in the research. When estrogen levels fall, the brain must find new ways to produce energy. Some evidence suggests that the brain can cannibalize itself using compounds that are important for maintenance brain function as fuel, which potentially drives neurodegeneration. Initiating HRT during menopause or can soon stop this shift, says Brinton. But if the brain has already made this transition, it can be too HRT to have an effect, she says.

“We need more studies to find out the solution to this confusion,” says Vaibhav. Without a clearer understanding of HRT’s effects, “women may miss the benefits or women can be in harm,” he says.